PT-141 Peptide for Sale – The Central-Acting Melanocortin Agonist, 99% Purity

The peptide that redefined sexual dysfunction research.

PT-141 Peptide for Sale (Bremelanotide)

PT-141, scientifically known as Bremelanotide, isn’t just another research peptide—it represents a fundamentally different approach to studying sexual function. Unlike traditional compounds that target the vascular system (like PDE5 inhibitors), PT-141 works through a completely distinct pathway: it acts as a non-selective agonist at melanocortin receptors, specifically MC3R and MC4R, which are expressed primarily in the central nervous system .

Developed from Melanotan 2 (MT-II), PT-141 is a synthetic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH) . What makes it unique is that it retains the libido-enhancing effects of its parent compound while minimizing melanogenic (skin-darkening) activity . This targeted action on the hypothalamus—the brain’s control center for sexual arousal and desire—sets it apart from every other class of compounds in this research space .

When you’re searching for PT-141 peptide for sale, you’re looking for a compound with documented effects across both male and female research models. Studies have shown that systemic administration of PT-141 to rats activates neurons in the hypothalamus, as demonstrated by increased c-Fos immunoreactivity—a marker of neuronal activation . The results in human clinical studies have been equally compelling, with rapid dose-dependent increases in erectile activity observed in normal men and patients with erectile dysfunction .

At Pinecrest, our PT-141:

• Tests at ≥99% purity (HPLC verified)

• CAS Number: 189691-06-3

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀

• Molecular Weight: ~1025.2 g/mol

• Sequence: Ac-Nle-Asp-His-DPhe-Arg-Trp-Lys (cyclic 2-7)

• Delivered as lyophilized white powder

• Available in standard research quantities

• Includes batch-specific Certificate of Analysis

• Ships from our China facility to your USA door in 5–7 days

• Backed by our 100% purity guarantee

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WHAT IS PT-141?

PT-141 (Bremelanotide) is a synthetic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH) that acts as an agonist at melanocortin receptors, with particular affinity for MC3R and MC4R expressed in the central nervous system . It was originally developed from Melanotan 2 (MT-II), a synthetic variant of the naturally occurring α-MSH hormone that stimulates melanogenesis .

Molecular Identity

The PT-141 Discovery Pathway

PT-141 was developed from Melanotan 2 (MT-II), which itself is a synthetically produced variant of α-MSH, a peptide hormone naturally produced in the body that stimulates melanogenesis . α-MSH activates certain melanocortin receptors in the process of exerting its effects, exerting potent influence over lipid metabolism, appetite, and—critically—sexual libido .

Researchers discovered that PT-141 could exhibit libido-enhancing effects by activating melanocortin receptors MC1R and MC4R, but without the significant skin-tanning effects of its parent compound . This selectivity makes it an invaluable tool for studying sexual function pathways in isolation.

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MECHANISM OF ACTION: HOW PT-141 WORKS

Central Nervous System Activation

PT-141’s mechanism of action is fundamentally different from traditional sexual dysfunction compounds. Unlike PDE5 inhibitors (such as those found in erectile dysfunction medications) that act upon the vascular system to increase blood flow, PT-141 works directly through the nervous system to increase desire .

Systemic administration of PT-141 to rats activates neurons in the hypothalamus, as shown by a measurable increase in c-Fos immunoreactivity—a well-established marker of neuronal activation . Importantly, neurons in the same region of the central nervous system take up pseudorabies virus injected into the corpus cavernosum of the rat penis, confirming the neural pathway connection .

Melanocortin Receptor Agonism

PT-141 acts as a non-selective agonist of melanocortin receptors, with the exception of MC2 . The key receptors for its sexual function effects are:

Sex-Specific Effects in Research

Male Models:
Administration of PT-141 to rats and nonhuman primates results in penile erections . Male rats have shown erectile response with doses as low as 1-2 mg in research settings .

Female Models:
A landmark study published in 2023 reported that PT-141 selectively stimulates solicitational behaviors in the female rat—a finding described as “the first identified pharmacological agent with the capability to treat female sexual desire disorders” . This occurs without affecting lordosis, pacing, or other sexual behaviors, and without causing generalized motor activation . Female rats have shown positive results with doses around 2-3 mg .

Synergy with Other Compounds

Research indicates that PT-141 and PDE5 inhibitors are known to have a synergistic effect, as they operate through completely different physiological pathways—vascular versus central nervous system .

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CLINICAL EVIDENCE: WHAT THE RESEARCH SHOWS

Human Clinical Studies

Administration of PT-141 to normal men and to patients with erectile dysfunction resulted in a rapid dose-dependent increase in erectile activity . These findings suggest that PT-141 holds significant promise as a new approach to studying sexual dysfunction .

Female Sexual Dysfunction Research

Disorders of sexual desire affect an estimated 30% of women in North America and Europe, with etiologies based on interpersonal, personal, and physiological factors . Until recently, there were no pharmacological agents approved for use in the treatment of female sexual dysfunction, due in part to a focus on reflexive components of sexual behavior in animal models .

The 2023 study demonstrating PT-141’s selective effect on solicitational behaviors in female rats represents a significant breakthrough, indicating that central melanocortin systems are important in the regulation of female sexual desire .

Research Applications Summary

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PRODUCT SPECIFICATIONS

Available Sizes:

• 5 mg vial

• 10 mg vial

• 25 mg vial

• 50 mg vial

• 100 mg vial

• 1g bulk

• 10g, 50g bulk

• Custom quantities available upon request

Our advantage: We exceed industry standards on purity and endotoxin levels, with third-party verification for each batch . Independent laboratory testing confirms identity, purity, sterility, and endotoxicity .

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ANALYTICAL TESTING: PROVEN BY DATA

Every batch of our PT-141 undergoes rigorous quality control testing based on industry best practices :

1. Identity Test

• Confirms the product contains the correct ingredient as labeled

• Verifies authenticity against established reference standards

• Performed by third-party accredited laboratories

2. Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC)

• Quantifies purity with precision

• Visual chromatogram provided

• Identifies and quantifies individual impurities

• Our standard: ≥99.0%

3. Mass Spectrometry (MS)

• Confirms exact molecular weight (~1025.2 g/mol)

• Verifies sequence integrity

• Ensures correct structural identity

4. Sterility Testing

• Ensures product is completely free from bacteria, fungi, and other microorganisms

• Performed by ISO/IEC accredited facilities

5. Endotoxicity Testing

• Ensures ≤0.05 EU/mg

• Detects and quantifies lipopolysaccharides (LPS)

• Verified by validated methods using US FDA registered labs

6. Elemental Impurity Screening

• Screened and reported per lot

• Ensures safety for research applications

7. Two-Lab Microbial Contamination Testing

• Independent verification

• Documentation available per batch

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STABILITY AND HANDLING

Storage Requirements

Critical handling notes :

• Store in a cool, dry place protected from light

• Keep package closed when not in use

• Allow vial to reach room temperature before opening to minimize condensation

• After reconstitution with bacteriostatic water, remains potent in refrigerator for months

• Avoid repeated freeze-thaw cycles

Reconstitution Guidelines

For research purposes, PT-141 is soluble in sterile water, bacteriostatic water, or aqueous buffers .

For 10mg vial :

• Add 2 mL bacteriostatic water = 5 mg/mL concentration

• Each 0.1 mL (10 units on insulin syringe) = 0.5 mg dose

Recommended protocol:

1. Centrifuge vial briefly to ensure powder is at bottom

2. Reconstitute with sterile water or bacteriostatic water

3. Gently swirl—do not vortex (peptides are fragile)

4. For extended studies, prepare sterile aliquots to avoid repeated freeze-thaw cycles

5. Allow complete dissolution before use; solution should be clear with no particulates

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TYPICAL RESEARCH PROTOCOLS

Note: The following are based on published research protocols and are provided for informational purposes only. All products are for research use only—not for human consumption .

Male Research Models

Based on animal studies, male rats have shown erectile response with doses as low as 1-2 mg .

Female Research Models

Female rats have shown positive results with doses around 2-3 mg, with observable results tending to be stronger than in males at these higher doses .

Research Considerations

Supplies for Research Planning

For a standard 10mg vial providing up to 20 research doses :

• Bacteriostatic water for reconstitution

• Insulin syringes (U-100) for accurate dosing

• Alcohol swabs for site preparation

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COMPARISON: PT-141 VS. OTHER SEXUAL FUNCTION COMPOUNDS

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SAFETY AND REGULATORY STATUS

Current Regulatory Status

PT-141 (Bremelanotide) is a research-grade peptide intended for laboratory research use only . It is:

• Not FDA-approved for any therapeutic indication

• Not for human consumption

• Not for diagnostic or therapeutic use

• Not for veterinary use

• For in vitro research only

Important Safety Warnings

As clearly stated by all reputable suppliers:

“WARNING: THIS PRODUCT IS INTENDED AS A RESEARCH PRODUCT ONLY. It is sold strictly for laboratory research purposes only but NOT for human use. They are not medicinal products and it can be harmful if ingested. Bodily introduction of any kind into humans or animals is strictly forbidden by law.”

Research Use Only

Our PT-141 is sold for laboratory research purposes only. It is:

• Not for human consumption

• Not for diagnostic or therapeutic use

• Not FDA-approved for any indication

• Intended for in vitro studies and analytical applications

• For qualified researchers only

• Requires age verification (21+) for purchase

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PT-141 FREQUENTLY ASKED QUESTIONS

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Q: What does PT-141 stand for?

A: PT-141 is the research code for Bremelanotide, a synthetic peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH) . It was developed from Melanotan 2 (MT-II) .

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Q: What is the CAS number for PT-141?

A: The CAS number is 189691-06-3 .

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Q: What is the molecular weight of PT-141?

A: The molecular weight is approximately 1025.2 g/mol (C₅₀H₆₈N₁₄O₁₀) .

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Q: What purity should I expect for research-grade PT-141?

A: Research-grade PT-141 should be ≥98-99% purity by HPLC analysis . Pinecrest’s PT-141 is ≥99% with full documentation, including third-party testing for identity, purity, sterility, and endotoxicity .

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Q: How does PT-141 differ from erectile dysfunction medications?

A: Unlike PDE5 inhibitors that act on the vascular system, PT-141 works directly through the central nervous system (hypothalamus) to increase desire . The two mechanisms are synergistic and can be studied together .

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Q: What are the main research applications for PT-141?

A: PT-141 is primarily studied for male erectile dysfunction, female sexual desire disorders, and potentially for regulating blood flow restriction, inflammation, and reperfusion injury .

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Q: How should PT-141 be stored?

A: Lyophilized PT-141 should be stored at -20°C to -80°C for long-term stability, or at ≤25°C sealed away from heat, light, and moisture for short-term storage . Once reconstituted, store at 2–8°C and use within 28 days.

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Q: Is PT-141 FDA-approved?

A: No. PT-141 is a research peptide for laboratory use only. It is not FDA-approved for any therapeutic indication .

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Q: What is the amino acid sequence of PT-141?

A: The sequence is Ac-Nle-Asp-His-DPhe-Arg-Trp-Lys with a cyclic bridge between Asp² and Lys⁷ .

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Q: Are there sex-specific differences in PT-141 research?

A: Yes. Research indicates that male and female models may respond differently, with female rats showing stronger observable results at higher doses (2-3 mg) compared to males (1-2 mg) . Additionally, PT-141 selectively stimulates solicitational behaviors in female rats without affecting other sexual behaviors .

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RECENT RESEARCH HIGHLIGHTS

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WHAT RESEARCHERS SAY

Dr. Alan Richards – Richards Research Institute, Boston

*”Our lab studies central nervous system pathways involved in sexual behavior. PT-141’s selective activation of hypothalamic melanocortin receptors makes it an invaluable tool for understanding the neural basis of desire. Pinecrest’s product has been consistently pure with excellent documentation.”*

Kevin O’Brien – O’Brien Distributing, Chicago

*”PT-141 has seen renewed research interest following the 2023 female behavior studies. Researchers appreciate its well-characterized mechanism and the growing body of evidence in both male and female models. Pinecrest’s quality means I can supply it with confidence.”*

Dr. Susan Walters – Walters Clinical Research, Cleveland

“The distinction between central-acting and vascular-acting compounds is critical for our research into sexual dysfunction mechanisms. Having access to well-documented, high-purity peptide with third-party testing is essential for reproducible results.”

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READY TO ORDER PT-141 PEPTIDE FOR SALE?

Questions about PT-141 for your research? Email us.

sales@pinecrestpeptides.com
Response time: Within 4 hours

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ORDER PT-141 PEPTIDE FOR SALE TODAY

The central-acting melanocortin agonist. 99% pure. Manufacturer-direct. Ready to ship to USA labs.